Study Overview

Copenhagen Baby Heart Study | CBHS


Copenhagen Baby Heart Study

Copenhagen Baby Heart Study, (CBHS) is the world’s largest population study examining the hearts of newborn babies.

Through April 1, 2016 to Oct. 31, 2018, all expectant parents at three large hospitals in the Copenhagen capital region were invited to participate in the study, offering a comprehensive cardiac examination of their child, preferably within the first 14 days after birth.

The hospitals included were Herlev Hospital, Hvidovre Hospital and Rigshospitalet. The examination consisted of an echocardiography, a heart diagram (ECG) and a measurement of the blood oxygen level.

CBHS also gathered information regarding the parents’ health and socioeconomic status. Furthermore, the study collected information about the pregnancy and birth as well as an umbilical cord blood sample at birth which is stored in a biorepository.

The purpose of CBHS is to study the cardiovascular structure and function of the newborn and better understand how factors before and after birth affect the heart’s structure and function.


Copenhagen Baby Heart Study-Impact

Copenhagen Baby Heart Study – Impact, CBHS-I, is a follow-up study of the population study CBHS. Whereas CBHS examined a large, unselected population of newborns, the aim of CBHS-I is to follow-up subgroups of children to determine the significance of larger and smaller abnormalities found in CBHS. During CBHS-I we will continue to follow children with minor heart abnormalities or born to mothers with certain risk factors, e.g. diabetes throughout their lives. In addition, families of children diagnosed with conditions suspected to be hereditary will be invited to participate. Additionally, participants will be followed lifelong through the means of large Danish registries (CPR registret, Landspatient registret).

We expect CBHS-I to help us understand how pre- and postnatal exposures affect cardiovascular structure and function and general health later in life and to determine which findings that are significant and require follow-up and which findings that are harmless.