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Area of research: pharmacy and congenital heart disease.
Primary supervisor: Henning Bundgaard and Kasper Iversen
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Ny publikation fra CBHS om højt blodtryk under graviditetens betydning for det nyfødte barn hjerte
Dansk:
Børn af mødre med svangerskabsforgiftning fødes med subkliniske morfologiske og funktionelle forandringer i det nyfødte barns hjerte, inklusive tykkere vægge af venstre pumpekammer og subkliniske systoliske og diastoliske forandringer. Derimod påvirker gestationel hypertension hos moder under graviditeten ikke det nyfødte barns ekkokardiografiske mål ved fødslen.
Studiet understreger vigtigheden af et øget fokus på svangerskabsforgiftning som en potent risikofaktor for hjertesygdom hos barnet. Der er dog behov for yderligere forskning til at afgøre om disse fund er permanente, samt hvorvidt denne gruppe børn burde tilbydes opfølgning igennem livet.
Maternal Hypertensive Disorders of Pregnancy and Cardiac Structure and Function in the Newborn
Læs den medhørende editorial i JACC: Advances
English:
Maternal preeclampsia, but not gestational hypertension, was associated with subtle newborn cardiac morphological and functional alterations, including thickening of the left ventricular myocardium and altered systolic and diastolic function.
This study underlines the importance of preeclampsia as a potent factor affecting foetal cardiac development. Further research is needed to determine if these abnormalities are permanent and whether increased awareness and early management of these offspring should be provided.
Maternal Hypertensive Disorders of Pregnancy and Cardiac Structure and Function in the Newborn
Unpublished
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by Sillesen AS, Iversen K
ABSTRACT
BACKGROUND: The Copenhagen Baby Heart Study (CBHS) is a population-based cohort study of neonates (N = 25,000), including echocardiography. Echocardiography in neonates is mainly focused on congenital heart disease (CHD), whereas general aspects of cardiac dimensions and function in neonates without CHD remain to be further addressed.
PURPOSE: This study was conducted to assess the reliability of neonatal echocardiography and validity of echocardiographic methods used in the CBHS.
METHODS: Reliability and agreement were tested for two-dimensional (2D), M-mode, spectral Doppler, and tissue velocity echocardiography for the following. (1) Measurements: seven sonographers independently performed two measurement rounds: (a) measurement of the same 50 echocardiograms (n = 350 echocardiograms measured) and (b) repeated measurement of 25 of the 50 echocardiograms (n = 175 echocardiograms measured). (2) Acquisition: four sonographers independently performed two rounds of echocardiographic acquisition and subsequent measurement of the same 22 neonates (n = 176 acquisitions and measures). Intra- and interobserver variabilities were assessed by determinations of coefficient of variation (CV), intraclass correlation coefficient (ICC), Bland-Altman plot, and 95% limits of agreement.
RESULTS: (1) Measurements: we found intra- and interobserver ICC ≥ 0.67 for 2D parameters, except for left ventricular (LV) wall thicknesses and LV diameter (interobserver); ICC ≥ 0.84 for tricuspid annular plane systolic excursion (TAPSE); ICC ≥ 0.93 for pulsed-wave Doppler (PW); ICC ≥ 0.84 for continuous-wave Doppler; and ICC ≥ 0.87 for tissue velocity parameters. We found CV < 15% for all parameters except LV wall thicknesses. (2) Acquisition: we found intra- and interobserver ICC ≥ 0.69 for 2D parameters, except for LV wall thicknesses, aortic valve annulus (interobserver), and LV end-systolic diameter (interobserver); ICC = 0.45-0.49 for TAPSE; ICC = 0.48-0.64 for PW; and ICC ≥ 0.70 for continuous wave. We found CV < 15% for all parameters. CONCLUSIONS: Reliability of echocardiographic measurements and acquisition of cardiac dimensions and function were good for most parameters but lower for TAPSE (acquisition) and PW Doppler (acquisition) and poor for LV wall thicknesses. In general, echocardiography of cardiac dimensions and function in the neonate is reliable. Copyright © 2019 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved. KEYWORDS: Acquisition; Agreement; Echocardiography; Measurements; Neonate; Reliability
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Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion.
Sillesen AS, Iversen K
Abstract
Congenital heart diseases (CHDs) are reported in 0.8% of newborns. Numerous factors influence cardiovascular development and CHD prevalence, and possibly also development of cardiovascular disease later in life. However, known factors explain the probable etiology in only a fraction of patients. Past large-scale population-based studies have made invaluable contributions to the understanding of cardiac disease, but none recruited participants prenatally and focused on the neonatal period. The Copenhagen Baby Heart Study (CBHS) is a population-based study of the prevalence, spectrum, and prognosis of structural and functional cardiac abnormalities. The CBHS will also establish normal values for neonatal cardiac parameters and biomarkers, and study prenatal and early childhood factors potentially affecting later cardiovascular disease risk. The CBHS is an ongoing multicenter, prospective study recruiting from second trimester pregnancy (gestational weeks 18-20) (expected n = 25,000). Information on parents, pregnancy, and delivery are collected. After birth, umbilical cord blood is collected for biochemical analysis, DNA purification, and biobank storage. An echocardiographic examination, electrocardiography, and post-ductal pulse oximetry are performed shortly after birth. Infants diagnosed with significant CHD are referred to a specialist or admitted to hospital, depending on CHD severity. CBHS participants will be followed prospectively as part of specific research projects or regular clinical follow-up for CHD. CBHS design and methodology are described. The CBHS aims to identify new mechanisms underlying cardiovascular disease development and new targets for prevention, early detection, and management of CHD and other cardiac diseases presenting at birth or developing later in life.
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This content is before the more tag.
Right after this sentence should be a “continue reading” button of some sort.
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Welcome to image alignment! The best way to demonstrate the ebb and flow of the various image positioning options is to nestle them snuggly among an ocean of words. Grab a paddle and let’s get started.
On the topic of alignment, it should be noted that users can choose from the options of None, Left, Right, and Center. In addition, they also get the options of Thumbnail, Medium, Large & Fullsize.
The image above happens to be centered.
The rest of this paragraph is filler for the sake of seeing the text wrap around the 150×150 image, which is left aligned.
As you can see the should be some space above, below, and to the right of the image. The text should not be creeping on the image. Creeping is just not right. Images need breathing room too. Let them speak like you words. Let them do their jobs without any hassle from the text. In about one more sentence here, we’ll see that the text moves from the right of the image down below the image in seamless transition. Again, letting the do it’s thang. Mission accomplished!
And now for a massively large image. It also has no alignment.
The image above, though 1200px wide, should not overflow the content area. It should remain contained with no visible disruption to the flow of content.
And now we’re going to shift things to the right align. Again, there should be plenty of room above, below, and to the left of the image. Just look at him there… Hey guy! Way to rock that right side. I don’t care what the left aligned image says, you look great. Don’t let anyone else tell you differently.
In just a bit here, you should see the text start to wrap below the right aligned image and settle in nicely. There should still be plenty of room and everything should be sitting pretty. Yeah… Just like that. It never felt so good to be right.
And just when you thought we were done, we’re going to do them all over again with captions!
The image above happens to be centered. The caption also has a link in it, just to see if it does anything funky.
The rest of this paragraph is filler for the sake of seeing the text wrap around the 150×150 image, which is left aligned.
As you can see the should be some space above, below, and to the right of the image. The text should not be creeping on the image. Creeping is just not right. Images need breathing room too. Let them speak like you words. Let them do their jobs without any hassle from the text. In about one more sentence here, we’ll see that the text moves from the right of the image down below the image in seamless transition. Again, letting the do it’s thang. Mission accomplished!
And now for a massively large image. It also has no alignment.
The image above, though 1200px wide, should not overflow the content area. It should remain contained with no visible disruption to the flow of content.
And now we’re going to shift things to the right align. Again, there should be plenty of room above, below, and to the left of the image. Just look at him there… Hey guy! Way to rock that right side. I don’t care what the left aligned image says, you look great. Don’t let anyone else tell you differently.
In just a bit here, you should see the text start to wrap below the right aligned image and settle in nicely. There should still be plenty of room and everything should be sitting pretty. Yeah… Just like that. It never felt so good to be right.
And that’s a wrap, yo! You survived the tumultuous waters of alignment. Image alignment achievement unlocked!
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This is a paragraph. It should not have any alignment of any kind. It should just flow like you would normally expect. Nothing fancy. Just straight up text, free flowing, with love. Completely neutral and not picking a side or sitting on the fence. It just is. It just freaking is. It likes where it is. It does not feel compelled to pick a side. Leave him be. It will just be better that way. Trust me.
This is a paragraph. It is left aligned. Because of this, it is a bit more liberal in it’s views. It’s favorite color is green. Left align tends to be more eco-friendly, but it provides no concrete evidence that it really is. Even though it likes share the wealth evenly, it leaves the equal distribution up to justified alignment.
This is a paragraph. It is center aligned. Center is, but nature, a fence sitter. A flip flopper. It has a difficult time making up its mind. It wants to pick a side. Really, it does. It has the best intentions, but it tends to complicate matters more than help. The best you can do is try to win it over and hope for the best. I hear center align does take bribes.
This is a paragraph. It is right aligned. It is a bit more conservative in it’s views. It’s prefers to not be told what to do or how to do it. Right align totally owns a slew of guns and loves to head to the range for some practice. Which is cool and all. I mean, it’s a pretty good shot from at least four or five football fields away. Dead on. So boss.
This is a paragraph. It is justify aligned. It gets really mad when people associate it with Justin Timberlake. Typically, justified is pretty straight laced. It likes everything to be in it’s place and not all cattywampus like the rest of the aligns. I am not saying that makes it better than the rest of the aligns, but it does tend to put off more of an elitist attitude.
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This is a sticky post.
There are a few things to verify:
.sticky class if you are using the post_class() function to generate your post classes, which is a best practice.
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Putting special characters in the title should have no adverse effect on the layout or functionality.
Special characters in the post title have been known to cause issues with JavaScript when it is minified, especially in the admin when editing the post itself (ie. issues with metaboxes, media upload, etc.).
This is a test to see if the fonts used in this theme support basic Latin characters.
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| ? | @ | A | B | C | D | E | F | G | H |
| I | J | K | L | M | N | O | P | Q | R |
| S | T | U | V | W | X | Y | Z | [ | |
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| g | h | i | j | k | l | m | n | o | p |
| q | r | s | t | u | v | w | x | y | z |
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